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⚠️ What Are the Possible Side Effects of Peptides?

🧬 Common Side Effects (May Occur with Any Injectable Peptide):

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Written by Tiann Peterkin
Updated over 6 months ago

While many patients tolerate peptides very well, it's important to understand that all medications carry the potential for side effects, and peptides are no exception. Side effects can vary depending on the specific peptide, your body’s response, and your health history.

🧬 Common Side Effects (May Occur with Any Injectable Peptide):

  • Mild redness or irritation at the injection site

  • Headache or lightheadedness

  • Fatigue or feeling flushed

  • Nausea or digestive discomfort

  • Temporary water retention or bloating


🔍 Peptide-Specific Considerations

1. NAD+

  • Tingling, cramping, or flushing during or after injection

  • Possible fatigue or light headache if dosed too high

2. Sermorelin

  • Vivid dreams or temporary sleep disruptions when starting

  • Tingling/numbness (rare)

  • Mild joint stiffness or swelling in some users

3. Glutathione

  • Rare allergic reactions (itchiness or rash)

  • Abdominal discomfort or bloating

  • Slight skin lightening with prolonged use (often desired, but should be noted)


🛑 When to Contact a Provider

You should reach out to your provider immediately if you experience:

  • Severe injection site reactions (swelling, warmth, or pain)

  • Difficulty breathing or chest tightness

  • Hives, rash, or signs of an allergic reaction


💬 Final Note

Most side effects are mild and temporary, especially when peptides are taken as prescribed. Always follow your provider’s instructions and report anything unusual so adjustments can be made if needed.

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