What side effects are commonly experienced?

What Side Effects Are Commonly Experienced?

Like any medication, GLP-1 receptor agonists (such as semaglutide and tirzepatide) may cause some side effects, especially when first starting treatment. Most side effects are mild to moderate and tend to improve as your body adjusts to the medication.

1. Common Side Effects

These side effects are the most frequently reported and typically fade over time:

✅ Gastrointestinal Symptoms (most common)

Nausea – Often mild and improves within a few weeks. Taking medication with food can help.
Vomiting – Less common but can occur if nausea is severe.
Diarrhea – Usually temporary and manageable with hydration.
Constipation – Drinking water and eating fiber-rich foods can help regulate digestion.
Bloating or Gas – Some people report mild discomfort that resolves with time.

✅ Appetite & Taste Changes

Reduced appetite – This is part of how the medication aids weight loss.
Food aversions – Some people develop dislikes for certain foods, especially greasy or heavy meals.

✅ Fatigue & Dizziness

Some individuals experience mild fatigue or dizziness in the first few weeks. Staying hydrated and maintaining balanced nutrition can help.

✅ Mild Injection Site Reactions (for injectable versions like semaglutide and tirzepatide)

Redness, swelling, or irritation at the injection site may occur but usually goes away quickly.

2. Less Common But Possible Side Effects

While rarer, some people may experience:

⚠ Heartburn or Acid Reflux – Some report a burning sensation in the chest after eating.
⚠ Mild headaches – Often temporary and resolves as the body adjusts.
⚠ Mild Hair Shedding – Occurs in a small percentage of people due to rapid weight loss but is usually temporary.

3. Serious But Rare Side Effects

Although uncommon, certain side effects require immediate medical attention:

🚨 Severe Nausea, Vomiting, or Dehydration – If you can’t keep fluids down, contact your healthcare provider.
🚨 Signs of Pancreatitis – Severe stomach pain that radiates to the back, nausea, and vomiting.
🚨 Gallbladder Issues – Symptoms like upper-right abdominal pain, nausea, or jaundice (yellowing of skin/eyes).
🚨 Severe Allergic Reactions – Unusual swelling, difficulty breathing, or rash should be reported immediately.

4. How to Manage Side Effects

Most side effects improve over time, but here are some tips to minimize discomfort:

✔ Eat smaller meals – Avoid heavy, greasy foods that may worsen nausea.
✔ Stay hydrated – Drinking enough water can help with digestion and prevent headaches.
✔ Adjust timing – Some people find taking medication at night reduces nausea.
✔ Start with a lower dose – If side effects are strong, your provider may gradually increase the dosage.

5. Should I Be Concerned About Side Effects?

For most people, side effects are mild and temporary, improving within a few weeks. However, if you experience persistent or severe discomfort, it’s important to consult your healthcare provider.

💡 Our medical team is here to monitor your progress, help manage side effects, and adjust your treatment if needed.

Updated on: 25/02/2025